I am not really a TV person. I am probably the only person in America who has never seen an episode of Friends. But recently I started watching a series on USA Network called Touching Evil.
The show is based on a series from British TV (but then isn't this true for all the best shows). The premise is that a detective, David Creegan, was shot in the head and has recovered from the wound but it has left him oddly changed from the brain injury. The catch phrase of the show is, what didn't kill him, made him stranger.
The cases that he and his partner investigate aren't particularly different than the cases you see on other shows but the entire approach of the show is unique and interesting. If you haven't seen it, it is definitely worth checking out.